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Updated: Mar 20, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
A description of two cases of factor V deficiency
F Cerneca1, E Parco1, R Simeone1
1Servizio Analisi Chimico-Cliniche, Laboratorio di Patologia dell'Emostasi Istituto per l'Infanzia 'Burlo Garofulo', via dell'Istria 65/1, 34137 Trieste, Italy.*Servizio Analisi Chimico-Cliniche, Laboratorio di Patologia dell'Emostasi, Istituto per l'infanzia 'Burlo Garofolo'. Trieste, Italy.Servizio Analisi Chimico-Cliniche, Laboratorio di Patologia dell'Emostasi, Istituto per l'Infanzia 'Burlo Garofolo', Trieste, Italy.Pediatric Clinic, IRCSS Burlo Garofolo, Trieste, Italy.Pediatric Clinic, IRCSS Burlo Garofolo, Trieste, Italy.
Abstract:
We report two cases of factor V deficiency. A 12-year-old girl with thalassemia major was admitted for bone marrow transplant (mismatched). She was found to have a heterozygous deficiency of factor V (21%), but this was considered compatible with the transplant, which was performed without the support of suppernatant cryoprecipitate. A 14-year-old girl (factor V 2%) with a negative history (menarche at age 12, menstrual cycle regular and normal in quantity and length). One year previously she had complained of menorrhagia (length of period, 9 days); tests revealed server anaemia (Hb 4.9 g/dl). We show how even severe cases of factor V deficiency may often be silent, and not require transfusion in surgical procedures, thus avoiding the risks associated with such therapy.
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