Related Experiment Videos
Ontogeny of peptidylglycine alpha-amidating monooxygenase activity in rapidly mineralizing bone from neonatal mouse
R S Birnbaum1, G A Howard, B A Roos
1Geriatric Research, Education, and Clinical Center, VA Medical Center, Tacoma, WA 98493.
Endocrinology
|June 1, 1989
Abstract:
Peptidylglycine alpha-amidating monooxygenase is hormonally, developmentally, and nutritionally regulated. In several tissues concomitant changes in enzyme activity and the level of expression of a known amidated peptide have been demonstrated. We report that neonatal mouse calvarium, a rapidly mineralizing bone, has detectable amidation enzyme activity. The level of activity varied 3-10-fold during the first 9 d of life. Production of one or more amidated peptides by bone may be coordinately regulated.