Aminodextran polymer-functionalized reactive magnetic emulsions for potential theranostic applications
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Published on: July 4, 2017
Michele K Lima-Tenório1, Edgardo A Gómez Pineda2, Nasir M Ahmad3
1University of Lyon, F-69622 Lyon, France, University Lyon 1, Villeurbanne, CNRS, UMR 5007, LAGEP-CPE, 43 Bd. 11 Novembre 1918, Villeurbanne F-69622, France; State University of Maringá, Department of Chemistry, Av. Colombo, 5790, CEP 87020-900 Maringá, Paraná, Brazil.
Abstract:
Aminodextran (AMD) polymer was prepared via chemical grafting of hexamethylenediamine on oxidized dextran. Magnetic latex particles were successfully obtained by adsorption of positively charged AMD on negatively charged submicron magnetic emulsion. The adsorbed amount was found to be ranged from 20 to 1280mg of AMD per gram of dried magnetic dispersion. The AMD-coated magnetic emulsions were characterized by positive zeta potential in the pH range from 3 to 9 compared to bare seed magnetic emulsion. All the samples showed to be superparamagnetic property, even after the adsorption of the polymer. The developed magnetic submicron particles exhibited good potential for in vivo biomedical diagnosis applications as demonstrated by their higher T2 contrast-ability compared to Gd in magnetic resonance imaging (MRI) and hyperthermia.
