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Published on: July 4, 2017
Aminodextran polymer-functionalized reactive magnetic emulsions for potential theranostic applications
Michele K Lima-Tenório1, Edgardo A Gómez Pineda2, Nasir M Ahmad3
1University of Lyon, F-69622 Lyon, France, University Lyon 1, Villeurbanne, CNRS, UMR 5007, LAGEP-CPE, 43 Bd. 11 Novembre 1918, Villeurbanne F-69622, France; State University of Maringá, Department of Chemistry, Av. Colombo, 5790, CEP 87020-900 Maringá, Paraná, Brazil.
Aminodextran (AMD) polymer was grafted onto magnetic nanoparticles, creating positively charged AMD-coated magnetic emulsions. These superparamagnetic particles show promise for in vivo biomedical imaging and hyperthermia applications.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Polymer Chemistry
Background:
- Developing novel magnetic nanoparticles for biomedical applications is crucial.
- Surface modification of magnetic nanoparticles enhances their utility in diagnostics and therapeutics.
- Dextran-based polymers offer biocompatibility and tunable properties.
Purpose of the Study:
- To synthesize and characterize aminodextran (AMD)-coated magnetic submicron particles.
- To evaluate the potential of these modified particles for in vivo biomedical diagnosis.
- To assess their performance in magnetic resonance imaging (MRI) and hyperthermia.
Main Methods:
- Chemical grafting of hexamethylenediamine onto oxidized dextran to prepare AMD polymer.
- Adsorption of positively charged AMD onto negatively charged submicron magnetic emulsion.
- Characterization using zeta potential measurements and assessment of magnetic properties.
- Evaluation of T2 contrast-ability for MRI and hyperthermia potential.
Main Results:
- Successfully prepared AMD-coated magnetic submicron particles with adsorbed amounts ranging from 20 to 1280 mg/g.
- Achieved positive zeta potential in the pH range of 3-9, indicating surface charge modification.
- Confirmed superparamagnetic properties of the particles post-polymer adsorption.
- Demonstrated higher T2 contrast-ability compared to Gadolinium (Gd) for MRI applications.
Conclusions:
- AMD-coated magnetic submicron particles are successfully synthesized.
- The developed particles possess favorable characteristics for in vivo biomedical diagnosis.
- Their enhanced T2 contrast-ability suggests significant potential in MRI and hyperthermia treatments.
