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The introduction of high-purity products in Canada

G H Growe1, C Rivet1

  • 1Transfusion Service, Vancouver Hospital & Health Sciences Centre, Vancouver, British Columbia, Canada,Canadian Blood Agency, Ottawa, Ontario, Canada.

Haemophilia : the Official Journal of the World Federation of Hemophilia
|May 24, 2016
PubMed

Insights

Canada transitioned to high-purity coagulation products in 1993, increasing costs but enabling practice monitoring. A collaborative working group effectively evaluated this product conversion and its impact.

Area of Science:

  • Hematology
  • Pharmacoeconomics
  • Public Health Policy

Background:

  • In October 1993, Canada adopted high-purity coagulation products (recombinant or purified factor concentrates) for managing coagulation deficiencies.
  • This shift led to a significant cost increase of approximately $30 million (40%) for the national inventory.

Purpose of the Study:

  • To monitor the impact of introducing new high-purity coagulation products.
  • To evaluate long-term outcomes including inhibitor formation, prophylaxis, immune status, and thrombosis incidence.
  • To develop clinical practice guidelines for Hemophilia and Von Willebrand's Disease.

Main Methods:

  • Establishment of a regular meeting forum for stakeholders (recipients, treaters, distributor, funders).
  • Implementation of a continuous usage monitoring system managed by the Canadian Blood Agency.
  • Inclusion of specific outcome studies by the Association of Hemophilia Clinic Directors of Canada.

Main Results:

  • Early identification of practice trends and rationales for unexpected product use.
  • Facilitation of planning and funding adjustments based on monitored data.
  • Effective evaluation of the conversion to new products and their national impact.

Conclusions:

  • The collaborative working group under the Canadian Blood Agency was effective in evaluating the product conversion.
  • The monitoring system provided early insights into practice trends and resource utilization.
  • This model can inform future endeavors in managing high-purity coagulation products.

Keywords:
Canadacoagulation productshigh purity

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