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Updated: Mar 20, 2026

Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes
Published on: June 3, 2014
Acquired inhibitor to factor VIII: report of two unusual cases
A V Pathare1, S Ghamande1, S Fernandes1
1Dr J C Patel Haematology Department, 10th Floor, King Edward VII Memorial Hospital, Mumbai - 400 012, India,Institute of Immunohematology (ICMR), 13th Floor, KEM Hospital, Mumbai - 400 012, India.
Abstract:
The present report describes two unusual cases of bleeding due to development of inhibitor against factor VIII. One of the patients was known to have severe haemophilia B (factor IX < 1%) and the other, a healthy male of 46 years, spontaneously started to bleed and was found to have developed inhibitors to factor VIII:C along with other autoantibodies. Development of inhibitors to coagulation factors is a serious clinical problem in de-veloped countries and is more so in developing countries where treatment options are often limited.
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