Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.7K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.7K
T Cell Types and Functions01:24

T Cell Types and Functions

3.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.1K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

13.7K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
13.7K
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

2.4K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.4K
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

304
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
304
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

3.2K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rewriting the Narrative on the Oncology Care Model.

JAMA·2026
Same author

Association of Participation in Medicare's Oncology Care Model With Spending, Utilization, and Quality Outcomes Among Commercially Insured and Medicare Advantage Members.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2024
Same author

Next-Generation Alternative Payment Models in Oncology-Will Precision Preclude Participation?

JAMA oncology·2023
Same author

The oncology care model and the future of alternative payment models: A gynecologic oncology perspective.

Gynecologic oncology·2021
Same author

The Oncology Care Model at 5 Years-Value-Based Payment in the Precision Medicine Era.

JAMA oncology·2021
Same author

Time to Rethink the Role of Clinical Pathways in the Era of Precision Medicine: A Lung Cancer Case Study.

JCO oncology practice·2021

Related Experiment Video

Updated: Mar 20, 2026

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

1.0K

Psoriasis: Pathogenesis, Assessment, and Therapeutic Update.

Stephen M Schleicher1

  • 1DermDOX Center for Dermatology, 20 North Laurel Street, Hazleton, PA 18201, USA; St. Luke's Health Systems, 801 Ostrum Street, Bethlehem, PA 18015, USA; The Commonwealth Medical College, Scranton, PA 18605, USA; University of Pennsylvania Medical College, Philadelphia, PA 19104, USA.

Clinics in Podiatric Medicine and Surgery
|May 25, 2016
PubMed
Summary

Psoriasis, a chronic skin condition affecting millions, is explored for its causes and symptoms. Advances in understanding its immune basis have led to new treatments alongside traditional therapies.

Keywords:
BiologicsPsoriasisPsoriatic arthritisPsoriatic comorbidities

More Related Videos

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.6K

Related Experiment Videos

Last Updated: Mar 20, 2026

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

1.0K
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.6K

Area of Science:

  • Immunodermatology
  • Chronic inflammatory skin diseases

Background:

  • Psoriasis is a prevalent chronic autoimmune condition.
  • It affects over 7 million Americans.
  • Understanding its immunologic basis is key to treatment.

Purpose of the Study:

  • To explore the pathogenesis of psoriasis.
  • To describe the physical signs of psoriasis.
  • To review current and emerging treatment modalities.

Main Methods:

  • Literature review of immunologic basis.
  • Description of clinical presentation.
  • Overview of systemic and traditional therapies.

Main Results:

  • Enhanced understanding of immune pathways in psoriasis.
  • Development of novel systemic agents.
  • Integration of new therapies with established treatments.

Conclusions:

  • Immunologic insights have transformed psoriasis management.
  • A combination of traditional and novel therapies offers improved outcomes.
  • Continued research is vital for further advancements.