Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Mar 20, 2026

Chronic Social Defeat Stress in Early Adolescent Male Mice
07:06

Chronic Social Defeat Stress in Early Adolescent Male Mice

Published on: January 24, 2025

1.7K

Negative occasion setting in juvenile rats.

Heidi C Meyer1, David J Bucci1

  • 1Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755, United States.

Behavioural Processes
|May 25, 2016
PubMed
Summary

Young rats (postnatal day 30) learn negative occasion setting as quickly as adult rats, unlike adolescent rats. This suggests a non-linear developmental trajectory for this crucial behavioral control mechanism.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety learning during adolescence facilitates fear regulation in adult mice.

Developmental cognitive neuroscience·2025
Same author

Environmental Enrichment Has Age- and Sex-Specific Effects on Fear Regulation in Mice.

Developmental psychobiology·2025
Same author

Examining threat responses through a developmental lens.

Cerebral cortex (New York, N.Y. : 1991)·2024
Same author

Adrenalectomy exacerbates stress-induced impairment in fear discrimination: A causal role for kynurenic acid?

Biochemical pharmacology·2024
Same author

Intermixed safety cues facilitate extinction retention in adult and adolescent mice.

Physiology & behavior·2023
Same author

Developmental age and fatty acid amide hydrolase genetic variation converge to mediate fear regulation in female mice.

Developmental psychobiology·2023

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Behavioral Science

Background:

  • Adolescent rats show deficits in using negative occasion setters compared to adults.
  • Negative occasion setting is crucial for behavioral flexibility and inhibitory control.

Purpose of the Study:

  • To investigate the developmental trajectory of negative occasion setting acquisition in rats.
  • To determine the age at which rats can effectively learn to use negative occasion setters.

Main Methods:

  • Rats were trained on a negative occasion setting task starting at postnatal days 30, 40, or 50.
  • Training involved pairing a tone with food reinforcement, with a light preceding the tone on non-reinforced trials.
  • The number of training sessions required to discriminate between trial types was recorded.
Keywords:
AdolescenceBehaviorInhibitionLearning

More Related Videos

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice
07:15

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice

Published on: March 15, 2024

2.9K
Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats
11:01

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

Published on: December 14, 2014

10.4K

Related Experiment Videos

Last Updated: Mar 20, 2026

Chronic Social Defeat Stress in Early Adolescent Male Mice
07:06

Chronic Social Defeat Stress in Early Adolescent Male Mice

Published on: January 24, 2025

1.7K
Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice
07:15

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice

Published on: March 15, 2024

2.9K
Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats
11:01

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

Published on: December 14, 2014

10.4K

Main Results:

  • Rats initiating training at postnatal day 50 required 10 sessions, similar to young adults.
  • Rats initiating training at postnatal day 30 (pre-adolescents) also required only 10 sessions.
  • Rats initiating training at postnatal day 40 (adolescents) required more sessions than the postnatal day 30 group, but fewer than previously reported adolescent rats (postnatal day 35).

Conclusions:

  • Negative occasion setting development in rats is non-linear, with a critical period potentially occurring before adolescence.
  • Pre-adolescent rats demonstrate a capacity for negative occasion setting comparable to adults.
  • These findings are vital for understanding adolescent behavioral control and its underlying neural mechanisms.