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Acute and chronic effects of methylphenidate on cortical adrenoceptors in the rat
J F Mathieu1, A Ferron, K M Dewar
1Département de Physiologie, Faculté de Médecine, Université de Montreal, Québec, Canada.
European Journal of Pharmacology
|March 14, 1989
Abstract:
The effects of acute and chronic treatments with methylphenidate were examined on cortical adrenoceptors. A single dose of methylphenidate increased the affinity of [3H]prazosin and [3H]idazoxan binding sites. Acute and chronic methylphenidate treatments caused a down-regulation of alpha 1-adrenoceptors. There were no changes in cortical beta-adrenoceptors measured with [3H]dihydroalprenolol nor in endogenous monoamine levels. The alterations in alpha-adrenoceptors can be attributed to an indirect action of methylphenidate possibly through an accrued release of noradrenaline or tyramine.