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What timing of vaccination is potentially dangerous for children younger than 2 years?

Pauline Gras1, Anne-Charlotte Bailly1, Marion Lagrée1,2

  • 1a Univ. Lille, CHU Lille, Pediatric Emergency Unit & Infectious Diseases , Lille , France.

Human Vaccines & Immunotherapeutics
|May 25, 2016
PubMed

Insights

Identifying dangerous vaccination delays is crucial for child health. This study defined critical timelines for vaccine doses to prevent disease, aiming to improve pediatric immunization effectiveness.

Area of Science:

  • Pediatric Infectious Diseases
  • Immunization Practices
  • Public Health

Background:

  • Vaccine-preventable diseases persist despite high coverage rates.
  • Late or untimely vaccinations may contribute to disease occurrence in children.
  • Defining safe vaccination windows is essential for effective public health strategies.

Purpose of the Study:

  • To identify potentially dangerous vaccination delays for each vaccine dose in children under two years old.
  • To establish consensus among experts on maximum acceptable delays for pediatric vaccinations.
  • To inform future studies on vaccine effectiveness and improve childhood immunization quality.

Main Methods:

  • A 3-round Delphi process involving 37 French pediatric vaccine experts.
  • Literature review to generate items for 10 vaccine doses recommended before age two.
  • A 70% consensus cutoff was used for item reduction and consensus building.

Main Results:

  • Consensus was reached on maximum acceptable delays for 6 out of 10 vaccine doses.
  • Specific delays were identified: 15 days for DTaP-IPV/Hib, 1 month for MenC, and by age 11 for HepB completion.
  • These defined delays serve as critical indicators for vaccine timeliness.

Conclusions:

  • The Delphi process successfully identified critical vaccination delays for children under two.
  • These findings provide new indicators for assessing vaccine effectiveness and timeliness.
  • Improving adherence to these vaccination schedules can enhance protection against preventable diseases in children.

Keywords:
childrendangerous delayepidemiologyinfectious diseasespediatricstimelinessvaccine

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