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Antagonizing Integrin β3 Increases Immunosuppression in Cancer.

Xinming Su1, Alison K Esser1, Sarah R Amend1

  • 1Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, Missouri.

Cancer Research
|May 25, 2016
PubMed
Summary

Integrin β3 antagonists may worsen cancer by promoting M2 macrophages and reducing CD8(+) T cells. Targeting integrin β3 in immune cells could improve cancer therapy outcomes.

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