Related Experiment Video

Updated: Mar 20, 2026

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
06:08

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Published on: September 22, 2023

2.8K

Chronic rhinosinusitis, endothelial dysfunction, and atherosclerosis

Omer Celal Elcioglu1, Baris Afsar, Ali Bakan

  • 1Division of Nephrology, Department of Internal Medicine, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey.

American Journal of Rhinology & Allergy
|May 25, 2016
PubMed

Insights

Chronic rhinosinusitis (CRS) is linked to endothelial dysfunction and atherosclerosis. Patients with CRS showed poorer artery function (lower FMD) and thicker carotid arteries (higher CIMT) compared to controls.

Area of Science:

  • Cardiovascular Medicine
  • Otolaryngology
  • Inflammation Research

Background:

  • Chronic inflammation contributes to atherosclerosis and endothelial dysfunction (ED).
  • Chronic rhinosinusitis (CRS), an inflammatory condition, may be linked to ED and atherosclerosis development.

Purpose of the Study:

  • To examine the association between CRS and markers of atherosclerosis and ED.
  • Investigated were carotid intima-media thickness (CIMT), brachial artery flow-mediated dilation (FMD), and microalbuminuria.

Main Methods:

  • A cross-sectional study involving 38 CRS patients and 29 healthy controls.
  • Noninvasive assessments included CIMT and FMD; urine albumin-creatinine ratios were also measured.

Main Results:

  • CRS patients exhibited significantly lower FMD (p=0.031) and higher CIMT (p=0.005) than controls.
  • Multivariate analysis confirmed independent associations between CIMT, FMD, and CRS.
  • No significant association was found between CRS and urinary albumin-creatinine ratio.

Conclusions:

  • CRS is associated with endothelial dysfunction and atherosclerosis, evidenced by reduced FMD and increased CIMT.
  • Further research is needed to elucidate the underlying pathophysiological mechanisms.
Abstract

More Related Videos

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies10:11

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies

Published on: October 22, 2014

19.8K
A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

18.2K

Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
5.0K
Chronic Pharyngitis01:23

Chronic Pharyngitis

Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
14.3K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
1.9K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
932
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
4.0K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.5K