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Area of Science:

  • Cardiovascular Medicine
  • Otolaryngology
  • Inflammation Research

Background:

  • Chronic inflammation contributes to atherosclerosis and endothelial dysfunction (ED).
  • Chronic rhinosinusitis (CRS), an inflammatory condition, may be linked to ED and atherosclerosis development.

Purpose of the Study:

  • To examine the association between CRS and markers of atherosclerosis and ED.
  • Investigated were carotid intima-media thickness (CIMT), brachial artery flow-mediated dilation (FMD), and microalbuminuria.

Main Methods:

  • A cross-sectional study involving 38 CRS patients and 29 healthy controls.
  • Noninvasive assessments included CIMT and FMD; urine albumin-creatinine ratios were also measured.

Main Results:

  • CRS patients exhibited significantly lower FMD (p=0.031) and higher CIMT (p=0.005) than controls.
  • Multivariate analysis confirmed independent associations between CIMT, FMD, and CRS.
  • No significant association was found between CRS and urinary albumin-creatinine ratio.

Conclusions:

  • CRS is associated with endothelial dysfunction and atherosclerosis, evidenced by reduced FMD and increased CIMT.
  • Further research is needed to elucidate the underlying pathophysiological mechanisms.