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Updated: Mar 20, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis and anti-proliferative activity of fluoro-substituted chalcones
Serdar Burmaoglu1, Oztekin Algul2, Derya Aktas Anıl3
1Tercan Vocational High School, Erzincan University, Erzincan 24800, Turkey; Department of Chemistry, Faculty of Science, Ataturk University, Erzurum 25240, Turkey.
Abstract:
A series of novel fluoro-substituted chalcone derivatives have been synthesized. All synthesized compounds were characterized by (1)H nuclear magnetic resonance (NMR), (13)C NMR, and elemental analysis. Their anti-proliferative activities were evaluated against five cancer cells lines, namely, A549, A498, HeLa, A375, and HepG2 using the MTT method. Most of the compounds showed moderate to high activity with IC50 values in the range of 0.029-0.729μM. Of all the synthesized compounds, 10 and 19 exhibited the most potent anti-proliferative activities against cancer cells, and 10 was identified as the most promising compound.
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