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Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

Ophthalmic Drug Delivery Systems

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

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Related Experiment Video

Updated: Mar 20, 2026

Author Spotlight: Enhancing Visual Outcomes in Cataract Surgery: A Novel Technique to Prevent Posterior Capsular Opacification Through IOL Rotation

Author Spotlight: Enhancing Visual Outcomes in Cataract Surgery: A Novel Technique to Prevent Posterior Capsular Opacification Through IOL Rotation

Published on: July 7, 2023

Managing coexistent cataract and glaucoma with iStent.

Christine L Larsen¹, Thomas W Samuelson¹

¹Minnesota Eye Consultants, P.A., Bloomington, Minnesota, USA.

Survey of Ophthalmology

|May 25, 2016

Summary

This summary is machine-generated.

The iStent, a microinvasive glaucoma surgery, safely lowers intraocular pressure in mild to moderate glaucoma. This intraocular implant offers a favorable safety profile compared to traditional filtering surgery.

Keywords:

Schlemm canal iStent microinvasive glaucoma surgery trabecular microbypass

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Ultrasound Cyclo Plasty in Eyes with Glaucoma

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Ultrasound Cyclo Plasty in Eyes with Glaucoma

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Published on: January 26, 2018

Area of Science:

Ophthalmology
Glaucoma Surgery
Medical Devices

Background:

Microinvasive glaucoma surgery (MIGS) is increasingly used for mild to moderate glaucoma.
The iStent provides a direct aqueous fluid bypass of the trabecular meshwork.
Traditional glaucoma filtering surgery carries risks like hypotony and endophthalmitis.

Purpose of the Study:

To review the safety and efficacy of the iStent for glaucoma treatment.
To provide an overview of iStent implantation techniques and postoperative expectations.
To discuss the potential of future iStent generations and multiple stent use.

Main Methods:

Review of existing publications on iStent safety and efficacy.
Discussion of iStent implantation technique.
Analysis of postoperative outcomes and potential complications.

Main Results:

The iStent demonstrates a favorable safety profile, comparable to cataract surgery.
It effectively lowers intraocular pressure in mild to moderate glaucoma.
Complication risks are minimized compared to transscleral filtering surgery.

Conclusions:

The iStent is a safe and effective option for managing mild to moderate glaucoma.
It presents a lower risk profile than traditional glaucoma surgeries.
Future iStent developments may enhance implantation and expand use to advanced disease.