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Updated: Mar 20, 2026

Detection of Glycosaminoglycans by Polyacrylamide Gel Electrophoresis and Silver Staining
Published on: February 25, 2021
Drugs affecting glycosaminoglycan metabolism
Giancarlo Ghiselli1, Marco Maccarana2
1Glyconova Srl, Parco Scientifico Silvano Fumero, Via Ribes 5, 10010 Colleretto Giacosa (TO), Italy.
Abstract:
Glycosaminoglycans (GAGs) are charged polysaccharides ubiquitously present at the cell surface and in the extracellular matrix. GAGs are crucial for cellular homeostasis, and their metabolism is altered during pathological processes. However, little consideration has been given to the regulation of the GAG milieu through pharmacological interventions. In this review, we provide a classification of small molecules affecting GAG metabolism based on their mechanism of action. Furthermore, we present evidence to show that clinically approved drugs affect GAG metabolism and that this could contribute to their therapeutic benefit.
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