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Combining Analysis of DNA in a Crude Virion Extraction with the Analysis of RNA from Infected Leaves to Discover New Virus Genomes
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Bioinformatics tools for analysing viral genomic data.

R J Orton, Q Gu, J Hughes

    Revue Scientifique Et Technique (International Office of Epizootics)
    |May 25, 2016
    PubMed
    Summary
    This summary is machine-generated.

    High-throughput sequencing (HTS) drives viral genomics research, enabling rapid genome analysis and discovery. Bioinformatics tools are crucial for processing the complex data generated by HTS technologies.

    Keywords:
    Bio-informatiqueGenomiqueGestion de donneesSequencage haut-debitVirologie

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    Area of Science:

    • Genomics
    • Bioinformatics
    • Virology

    Background:

    • High-throughput sequencing (HTS) has revitalized viral genomics.
    • HTS allows rapid, cost-effective sequencing and assembly of viral genomes.
    • It also enables analysis of intra-host viral diversity and dynamics.

    Purpose of the Study:

    • To provide an overview of bioinformatics tools for viral genomics.
    • To highlight the applications of HTS technologies in viral research.
    • To summarize key HTS analysis steps.

    Main Methods:

    • Overview of bioinformatics tools for viral genomics.
    • Emphasis on HTS technologies and their applications.
    • Summary of HTS analysis pipeline.

    Main Results:

    • HTS facilitates rapid viral genome sequencing, assembly, and discovery.
    • Analysis of viral diversity, transmission, and host jumping is enhanced.
    • Bioinformatics is essential for managing and analyzing large HTS datasets.

    Conclusions:

    • HTS and bioinformatics are transforming viral genomics and discovery.
    • These technologies offer powerful tools for understanding viral evolution and disease.
    • Continuous development of algorithms and software is vital for advancing the field.