Effects of Complementary Creatine Monohydrate and Physical Training on Inflammatory and Endothelial Dysfunction
Farajollah Hemati1, Asghar Rahmani2, Khairollah Asadollahi3
1Department of Sports Medicine, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, IR Iran.
Insights
Creatine monohydrate and exercise significantly reduced inflammation and endothelial dysfunction markers in heart failure patients. This combination therapy offers a promising approach to managing these conditions.
Area of Science:
- Cardiology
- Exercise Physiology
- Nutritional Science
Background:
- Heart failure (HF) is associated with endothelial dysfunction and elevated inflammatory cytokines.
- Understanding factors that influence these markers is crucial for HF management.
Purpose of the Study:
- To investigate the impact of creatine monohydrate combined with exercise on inflammatory and endothelial dysfunction markers in HF patients.
- To assess changes in specific biomarkers following an 8-week intervention.
Main Methods:
- 100 HF patients were randomized into an intervention group (creatine monohydrate + exercise) and a control group.
- Interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), P-selectin, ICAM-1, and VCAM-1 were measured at baseline and after 8 weeks.
Main Results:
- The intervention group showed decreased levels of hs-CRP, IL-6, P-selectin, and ICAM-1 compared to baseline.
- The control group exhibited increased levels of hs-CRP and IL-6.
- VCAM-1 levels did not significantly decrease in the intervention group.
Conclusions:
- Combining creatine monohydrate with exercise effectively attenuates key markers of inflammation and endothelial dysfunction in heart failure patients.
- This therapeutic strategy holds potential for improving cardiovascular health in HF populations.
Background:
Previous studies have reported endothelial dysfunction and inflammatory cytokine in heart failure patients (HF).
Objectives:
The purpose of this study was to determine the effects of creatine monohydrate and exercise on inflammatory and endothelial dysfunction markers among HF patients.
Patients And Methods:
One hundred patients were prospectively randomized into two groups: Intervention group which received 5 grams/day creatine monohydrate and exercised for 8 weeks; and control group which did not receive any interventions. Interleukine-6 (IL-6), high sensitivity C reactive protein (hs-CRP), P-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1) were measured at the start and end of the study for both groups.
Results:
In total, 100 patients including 50 controls and 50 intervention group (54% male, mean EF of 34.2 ± 10.5% and 52% male, mean EF of 35.6 ± 12.7%, respectively) were analyzed. The serum levels of hs-CRP and IL-6 increased at the end of the study in the control group compared to the baseline, (7.5 ± 1.5 mg/L vs. 6.9 ± 1.3 mg/L, P < 0.05 and 3.0 ± 0.75 ng/L vs. 2.55 ± 0.9 ng/L, P < 0.05, respectively). However, compared to the baseline, the level of both markers decreased at the end of the study in the intervention group (6.3 ± 1.6 mg/L vs.7.5 ± 1.5 mg/L, P < 0.05 and 2.1 ± 0.8 ng/L vs.2.5 ± 0.5 ng/L, P < 0.05). Also, P-selectin and ICAM-1 levels increased at the end of study (56.9 ± 1.8 ng/L vs. 51.9 ± 1.5 ng/L, P < 0.05 and 368.1 ± 25.4 µg/L vs. 353.1 ± 10.4 µg/L, P < 0.05 respectively). Inversely, the levels of these markers decreased in the intervention group, at the end of study (49.7 ± 1.9 ng/l vs. 51.4 ± 2.1 ng/l, P < 0.05 and 342.7 ± 16.5 µg/l vs. 350.4 ± 14.7 µg/l, P < 0.05, respectively). VCAM-1 level was not decreased significantly at the end of the study in the intervention group (570.5 ± 78.4 µg/L vs. 575.3 ± 86.5 µg/L, P > 0.05).
Conclusions:
Combination of creatine monohydrate and exercise attenuated inflammation and endothelial dysfunction markers among heart failure patients.
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
01:29Heart Failure II: Pathophysiology
01:30Heart Failure V: Medical Management
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:22Heart Failure VI: Adjunct Therapies