[Reaction and effectiveness of prednisolone in zinc oxide containing dermatologic agents]

The ions of prednisolone and zinc are reacting in a mole proportion of 2:1, and are forming a defined compound according to the formula ZnL2 (L = prednisolone anion). This was proven by potentiometrical equilibrium investigations. Therefore the application of prednisolone within zinc oxide containing dermatics is less indicated. The limited usability and reduced effectiveness of prednisolone containing zinc oxide-dermatics forbid a central production and storage for a longer time.