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Epstein-Barr virus-associated leukemic lymphoma after allogeneic stem cell transplantation

Hiroyuki Takamatsu1, Raita Araki2, Ryosei Nishimura2

  • 1Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8641, Japan.

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
|May 25, 2016
PubMed

Leukemic Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative diseases (PTLD) following allogeneic hematopoietic stem cell transplantation are extremely rare. We can successfully treat an EBV-associated leukemic lymphoma patient with rituximab, cidofovir, and donor lymphocyte infusion (DLI). In the present case, EBV-specific T cells that were present in the peripheral blood before rituximab administration treatment rapidly increased after DLI in association with a decrease in the EBV-DNA load.

Keywords:
CidofovirDonor lymphocyte infusionEpstein–Barr virusPost-transplant lymphoproliferative diseaseRituximab

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