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Visualization of Surface-tethered Large DNA Molecules with a Fluorescent Protein DNA Binding Peptide
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A Surface-Confined Proton-Driven DNA Pump Using a Dynamic 3D DNA Scaffold.

Dan Zhu1,2, Hao Pei1,3, Guangbao Yao1

  • 1Division of Physical Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China.

Advanced Materials (Deerfield Beach, Fla.)
|May 25, 2016
PubMed
Summary

Researchers developed a proton-driven molecular pump using a dynamic DNA nanostructure. This pH-responsive nanomachine can move water and ferricynide, demonstrating potential for nanoscale fluid transport.

Keywords:
DNA nanostructuresdynamic nanodevicesnanopumpsreversiblesurface-confined

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Area of Science:

  • Nanotechnology
  • Biotechnology
  • Materials Science

Background:

  • Developing efficient nanoscale pumps is crucial for various applications.
  • DNA nanostructures offer versatile platforms for creating molecular machines.

Purpose of the Study:

  • To devise a proton-driven molecular pump.
  • To utilize a surface-confined dynamic 3D DNA scaffold for controlled nanomachine operation.

Main Methods:

  • Designed a dynamic DNA tetrahedral nanostructure with a pH-sensitive i-motif sequence.
  • Confined the DNA nanostructure to a macroscopic gold surface to ensure ordered orientation.
  • Investigated the switching ability and pumping performance of the nanomachine in response to pH changes.

Main Results:

  • The dynamic DNA tetrahedron maintained its switching ability on the gold surface.
  • The proton-driven nanomachine successfully and reversibly pumped water and ferricynide.
  • The pumping action was directly controlled by variations in solution pH.

Conclusions:

  • A novel proton-driven molecular pump was successfully engineered using a surface-confined dynamic DNA scaffold.
  • The DNA-based nanomachine exhibits reversible pumping capabilities in response to pH stimuli.
  • This work demonstrates the potential of DNA nanostructures for creating responsive nanoscale devices.