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A pilot, single-arm feasibility study of a multidimensional behavioral intervention for cognitive fatigability in multiple sclerosis: Mental Energy Boost program.

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Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
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Is physical exercise a multiple sclerosis disease modifying treatment?

Robert W Motl1, Lara A Pilutti1

  • 1a Department of Kinesiology and Community Health , University of Illinois at Urbana-Champaign , Urbana , IL , USA.

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Exercise may modify multiple sclerosis (MS) progression. Physical activity shows potential in reducing relapses, mobility issues, and lesion volume, while improving neurological performance in MS patients.

Keywords:
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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Exercise Science

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease impacting function and symptoms.
  • Exercise is recognized as a behavioral strategy for managing MS.
  • The role of exercise as a disease-modifying treatment in MS requires further investigation.

Purpose of the Study:

  • To review the evidence for exercise and physical activity as disease-modifying treatments in MS.
  • To describe metrics for evaluating MS disease modification and progression.
  • To identify limitations in current research on exercise in MS.

Main Methods:

  • Literature review of individual studies, reviews, and meta-analyses on exercise and MS.
  • Summary of evidence linking physical activity to MS disease markers.
  • Analysis of metrics for MS disease progression and modification.

Main Results:

  • Exercise and physical activity are associated with reduced relapse rates in MS.
  • Evidence suggests exercise can decrease mobility disability and its progression.
  • Potential improvements in neuroperformance, particularly walking outcomes, have been observed.

Conclusions:

  • Exercise and physical activity show promise as disease-modifying strategies for MS.
  • Preliminary evidence indicates exercise may influence MS progression markers.
  • Further research is needed to fully understand the disease-modifying effects of exercise in MS.