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Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat
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Hypertensive patients with left ventricular hypertrophy have global left atrial dysfunction and impaired

Camille Soullier1, Joseph T Niamkey, Jean-Etienne Ricci

  • 1aCentre hospitalo-universitaire de Nimes, Nimes, France bInstitut de Cardiologie, Abidjan, Côte d'Ivoire.

Journal of Hypertension
|May 25, 2016
PubMed

Insights

Systemic arterial hypertension (HTN) with left ventricular (LV) hypertrophy impairs left atrial (LA) functions. LA dysfunction is linked to LV hypertrophy and filling pressures, suggesting fibrotic changes and highlighting LA-LV coupling importance.

Area of Science:

  • Cardiology
  • Echocardiography
  • Cardiac Physiology

Background:

  • Systemic arterial hypertension (HTN) is a major cause of left ventricular (LV) hypertrophy.
  • LV hypertrophy can lead to diastolic dysfunction and affect left atrial (LA) function.
  • Comprehensive assessment of LA function in HTN with LV hypertrophy is crucial.

Purpose of the Study:

  • To investigate left atrial (LA) reservoir, conduit, and booster pump functions in patients with HTN and LV hypertrophy.
  • To identify predictors of impaired LA function in this patient cohort.
  • To evaluate LA stiffness as an index in HTN with LV hypertrophy.

Main Methods:

  • Speckle-tracking echocardiography used to measure LA systolic and diastolic strains and strain rates.
  • Comparison of 30 HTN patients with LV hypertrophy against 29 normotensive controls.
  • LA stiffness assessed using the E/E'/S-LAs index.

Main Results:

  • HTN patients exhibited higher LV mass index, impaired LV diastolic function, and increased LA volume index.
  • Significantly reduced LA reservoir, conduit, and booster pump functions were observed in HTN patients.
  • Increased LV mass, LV filling pressures, reduced LV strain, and E' were predictors of reduced LA function.

Conclusions:

  • Patients with HTN and LV hypertrophy demonstrate impaired LA reservoir, conduit, and booster pump functions.
  • These functional impairments are correlated with LV hypertrophy and dysfunction.
  • LA-LV coupling is important, and LA fibrotic changes may contribute to observed dysfunction.
Abstract

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