[Digital modeling for the individual mandibular 3D mesh scaffold based on 3D printing technology]

Area of Science:

• Biomaterials Engineering
• Tissue Engineering
• Medical Device Design

Background:

• Mandibular bone defects pose significant challenges in reconstructive surgery.
• Current methods for bone defect restoration often have limitations in achieving optimal functional and aesthetic outcomes.
• Tissue engineering offers promising solutions for creating patient-specific implants.

Purpose of the Study:

• To establish an ideal modeling methodology for designing 3D mesh scaffold substitutes for mandibular bone defect restoration.
• To verify the feasibility and effectiveness of a 3D printing-based approach for fabricating these scaffolds.

Main Methods:

• Utilized CT data and reverse engineering software (Mimics, Geomagic) to create a 3D model of the mandible and defect.
• Employed mirror algorithm and CAD software (Unigraphics NX) for prosthesis and scaffold design.
• Integrated finite element analysis (ANSYS) for optimizing internal structure, strength, and weight.
• Fabricated titanium scaffolds using 3D printing technology.

Main Results:

• Successfully designed patient-specific 3D mesh scaffolds using two distinct modeling methods.
• Finite element optimization resulted in a 10% reduction in stress peak and a 43% decrease in volume.
• Achieved a scaffold porosity of 76.32%, indicating enhanced potential for tissue ingrowth.
• 3D printed titanium scaffolds validated the feasibility and effectiveness of the modeling approach.

Conclusions:

• The combination of 3D printing technology and finite element topology optimization provides a feasible and effective method for designing ideal mandibular 3D mesh scaffolds.
• This approach holds significant potential for improving the treatment of mandibular bone defects.