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Beyond transcription factors: how oncogenic signalling reshapes the epigenetic landscape

Fan Liu1,2, Lan Wang3,4, Fabiana Perna5

  • 1Department of Biochemistry and Molecular Biology, University of Miami, Miami, Florida 33136, USA.

Nature Reviews. Cancer
|May 26, 2016
PubMed

Insights

Cancer is a complex disease influenced by both genetic and epigenetic factors. Understanding epigenetic alterations and chromatin modifications is crucial for unraveling cancer

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Cancer is now recognized as a complex disease involving both genetic and epigenetic factors.
  • The epigenetic landscape, regulated by DNA and histone modifications, is significantly altered in cancer cells.
  • Aberrant epigenetic modifications can stem from mutations or altered expression of chromatin-modifying proteins.

Purpose of the Study:

  • To review recent studies on the interplay between cellular signaling pathways and epigenetic modifications in cancer.
  • To enhance understanding of the molecular pathogenesis of neoplasia through the lens of epigenetics.

Main Methods:

  • Review of current scientific literature and recent reports.
  • Analysis of the role of chromatin modifiers in cancer development.
  • Exploration of the connection between cell signaling and epigenetic regulation.

Main Results:

  • Epigenetic abnormalities are a hallmark of transformed cells.
  • Interactions between signaling pathways and chromatin modifications add complexity to epigenome regulation.
  • Mutations in chromatin modifiers contribute to epigenetic dysregulation in cancer.

Conclusions:

  • Epigenetic alterations are integral to cancer development.
  • Understanding these epigenetic changes offers new insights into cancer pathogenesis.
  • Further research into signaling pathways and chromatin modifications is essential for advancing cancer research.

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