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[Comorbidity in psoriasis].

S Gerdes1, U Mrowietz2, W-H Boehncke3

  • 1Psoriasis-Zentrum, Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Schittenhelmstr. 7, 24105, Kiel, Deutschland. sgerdes@dermatology.uni-kiel.de.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|May 26, 2016
PubMed
Summary

Psoriasis, a chronic inflammatory disease, is linked to numerous comorbidities like psoriatic arthritis, cardiovascular issues, and mental health conditions. Early detection and management of these associated conditions are crucial for patient care.

Keywords:
DepressionGeneticsInflammationObesityPsoriatic arthritis

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Area of Science:

  • Dermatology and Immunology
  • Systemic Inflammatory Diseases

Background:

  • Psoriasis is a chronic systemic inflammatory disease.
  • It is frequently associated with comorbidities including psoriatic arthritis, cardiovascular disease, metabolic syndrome, obesity, depression, and anxiety disorders.
  • These associations are partly explained by shared genetic and pathophysiological mechanisms, including immune system involvement.

Purpose of the Study:

  • To highlight the systemic nature of psoriasis and its associated comorbidities.
  • To emphasize the role of dermatologists in managing these comorbidities.
  • To introduce management concepts and screening tools for psoriatic comorbidity.

Main Methods:

  • Review of epidemiological studies and genetic research on psoriasis and its comorbidities.
  • Discussion of pathophysiological models like the 'psoriatic march'.
  • Description of developed management and screening strategies.

Main Results:

  • Approximately 40 psoriasis susceptibility loci have been identified, primarily related to the immune system.
  • Genetic overlap exists between psoriasis and some associated diseases, such as psoriatic arthritis.
  • The 'psoriatic march' model illustrates the progression to metabolic and cardiovascular diseases driven by systemic inflammation.

Conclusions:

  • Psoriasis management requires addressing its systemic nature and associated comorbidities.
  • Dermatologists play a key role in early detection and management of comorbidities.
  • Available tools and concepts support dermatologists in integrated patient care.