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[Treatment adherence with levetiracetam: a non-interventionist retrospective observation-based study]
P J Serrano-Castro1, J A Mauri-Llerda2, A Garcia3
1Hospital Torrecardenas, 04009 Almeria, Espana.
Revista De Neurologia
|May 26, 2016
Summary
Levetiracetam granulates in sachets improve treatment adherence compared to tablets, especially in elderly patients. This formulation enhances compliance in epilepsy management.
Area of Science:
- Neurology
- Pharmacology
- Patient Adherence Research
Background:
- Treatment adherence significantly impacts antiepileptic drug effectiveness.
- Levetiracetam's efficacy and safety are established, with various oral formulations available.
- Limited data exists on treatment adherence for different levetiracetam oral formulations.
Purpose of the Study:
- To evaluate and compare treatment adherence with levetiracetam granulates in sachets versus tablets.
- To assess adherence in both adult and elderly patient populations.
Main Methods:
- Retrospective, observational, non-interventionist study design.
- Inclusion of patients treated with levetiracetam (granulates or tablets) for three months prior.
- Utilized the Green-Morisky modified test for compliance and a satisfaction questionnaire.
Main Results:
- Compliance was significantly associated with pharmaceutical formulation and age (p=0.031).
- Patients taking levetiracetam tablets had an 86.4% higher risk of non-compliance compared to granulates in sachets.
- Higher non-compliance rates were observed in patients over 65 years old and linked to memory failure attributions.
Conclusions:
- Older patients exhibit greater challenges with treatment compliance.
- Levetiracetam granulates in sachets demonstrate improved patient compliance.
- Formulation choice is a key factor in optimizing adherence for levetiracetam therapy.
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