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Updated: Mar 20, 2026
Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
Published on: June 28, 2018
[Analysis of risk factors of ventilator-associated pneumonia in an intensive care unit]
Juan Wang1, De-Xian Li, Chao-Xian Yu
1Department of Severe Tuberculosis, Guangzhou Chest Hospital, Guangzhou 510095, China.E-mail: restto99@163.com.
Objective:
To explore the risk factors of ventilator-associated pneumonia (VAP) in patients admitted in an intensive care unit (ICU) for pulmonary tuberculosis (TB).
Methods:
The clinical data of 143 patients admitted in the ICU at our center between January, 2014 and June, 2015 were reviewed. The patients with VAP and those without VAP were analyzed for risk factors of VAP in the setting of an ICU for pulmonary TB and compared for the duration of ventilation and hospital stay.
Results:
The patients with pulmonary TB showed a significantly higher incidence of VAP in the ICU than those without TB. Univariate analysis suggested that the occurrence of VAP was significantly correlated with the duration of mechanical ventilation, invasive examination, pulmonary tuberculosis, lung structure changes, use of multiple antibiotics, diabetes, tracheal incision, indwelling gastric tube, APACHE II score, and coma (P<0.05). Multivariate logistic regression analysis showed that pulmonary TB, duration of mechanical ventilation, APACHE II score, invasive operation, and use of multiple antibiotics were independent risk factors for VAP (P<0.05). The patients who developed VAP had a prolonged duration of mechanical ventilation and ICU stay (P<0.05).
Conclusion:
Patients admitted in tuberculosis ICU are exposed to a high risk of VAP with a high mortality rate as the result of multiple interacting risk factors. Pulmonary TB, prolonged mechanical ventilation, an APACHE II score >15, invasive operation, and use of multiple antibiotics are all independent risk factors for VAP in tuberculosis ICU.
Insights
Ventilator-associated pneumonia (VAP) is a significant risk in intensive care units (ICUs) for patients with pulmonary tuberculosis (TB). Key risk factors include prolonged mechanical ventilation and invasive procedures.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Pulmonology
Background:
- Pulmonary tuberculosis (TB) patients admitted to the intensive care unit (ICU) face a heightened risk of developing ventilator-associated pneumonia (VAP).
- Understanding VAP risk factors in this specific population is crucial for improving patient outcomes.
Purpose of the Study:
- To identify and analyze the risk factors associated with ventilator-associated pneumonia (VAP) in patients with pulmonary tuberculosis (TB) admitted to an intensive care unit (ICU).
Main Methods:
- A retrospective review of clinical data from 143 patients admitted to a specialized ICU for pulmonary TB between January 2014 and June 2015.
- Analysis included comparing patients with and without VAP to identify significant risk factors and comparing ventilation and hospital stay durations.
Main Results:
- Patients with pulmonary TB exhibited a significantly higher incidence of VAP compared to non-TB patients.
- Independent risk factors for VAP identified through multivariate analysis include pulmonary TB, prolonged mechanical ventilation, high APACHE II scores, invasive operations, and the use of multiple antibiotics.
- VAP development was associated with longer mechanical ventilation duration and extended ICU stays.
Conclusions:
- Patients in tuberculosis ICUs are at high risk for VAP due to multiple interacting factors.
- Pulmonary TB, prolonged mechanical ventilation, an APACHE II score greater than 15, invasive operations, and multiple antibiotic use are identified as independent risk factors for VAP in this patient cohort.
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