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Updated: Mar 20, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Smoking-Thrombolysis Relationship Depends on Ischemic Stroke Subtype
Xu Tong1, Chunjuan Wang1, Xiaoling Liao1
1From the Department of Neurology (X.T., Chunjuan Wang, X.L., Y.P., H.Y., L.L., H.Z., X.Z., H.L., Yilong Wang, Yongjun Wang), Tiantan Clinical Trial and Research Center for Stroke (Chunjuan Wang, Y.P., H.Y., H.L., Yilong Wang, Yongjun Wang), Vascular Neurology (X.L., H.Z., X.Z., Yongjun Wang), Neuro-intensive Care Unit (L.L.), and Department of Neuropsychiatry and Behavioral Neurology and Clinical Psychology (Chunxue Wang), Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Neurology, Tangshan Gongren Hospital, Hebei Medical University, Tangshan, Hebei, China (X.T., Y.C.); China National Clinical Research Center for Neurological Diseases, Beijing, China (X.L., L.L., H.Z., X.Z., Chunxue Wang, H.L., Yilong Wang, Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (Chunjuan Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (Y.P.); and Illinois Neurological Institute Stroke Network, Sisters of the Third Order of St Francis Healthcare System, University of Illinois College of Medicine, Peoria (D.W.).
Smoking may improve functional independence in non-cardioembolic stroke patients receiving thrombolysis. It also reduces hemorrhage and mortality risk in large artery atherosclerosis stroke patients.
Area of Science:
- Neurology
- Cardiology
- Public Health
Background:
- The impact of smoking on thrombolysis outcomes in stroke patients is unclear.
- Stroke subtypes may influence the relationship between smoking and treatment efficacy.
Purpose of the Study:
- To investigate the effect of smoking on stroke outcomes in patients receiving intravenous thrombolysis.
- To analyze smoking's influence across different ischemic stroke subtypes.
Main Methods:
- Analysis of 1118 patients from the TIMS-China database who received intravenous thrombolysis.
- Classification of ischemic stroke subtypes using Trial of Org 10172 in Acute Stroke Treatment criteria.
- Logistic regression models to assess the relationship between smoking and outcomes (hemorrhage, mortality, functional independence).
Main Results:
- Smokers (n=454) and non-smokers (n=664) were compared.
- Smoking correlated with better functional independence in non-cardioembolic stroke subtypes (large artery atherosclerosis, small artery occlusion, other).
- Smoking was associated with lower symptomatic intracranial hemorrhage and mortality rates in large artery atherosclerosis stroke patients.
Conclusions:
- Smoking may enhance functional independence in non-cardioembolic stroke patients undergoing thrombolysis.
- For large artery atherosclerosis stroke, smoking is linked to reduced risks of symptomatic intracranial hemorrhage and mortality post-thrombolysis.
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