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Cleft uvula: prevalence and genetics.

A Chosack, E Eidelman

    The Cleft Palate Journal
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Cleft uvula (CU) affects 0.44% of children, with higher prevalence in Non-Ashkenazi groups. Family studies suggest a polygenic inheritance pattern for this condition.

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    Area of Science:

    • Genetics
    • Pediatrics
    • Oral and Maxillofacial Surgery

    Background:

    • Cleft uvula (CU) is a common oral anomaly.
    • Understanding its prevalence and inheritance patterns is crucial for genetic counseling and clinical management.

    Purpose of the Study:

    • To determine the prevalence of cleft uvula in a large cohort of school children.
    • To investigate the familial aggregation and potential mode of inheritance of cleft uvula.

    Main Methods:

    • A cross-sectional study of 70,359 school children aged 6-18 years.
    • A family study involving 90 probands with cleft uvula and their relatives.
    • Prevalence data collected through clinical examination.

    Main Results:

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  • The overall prevalence of cleft uvula was 0.44%, with no significant sex differences.
  • Higher prevalence observed in the Non-Ashkenazi population group.
  • Familial recurrence rates were 7.7% in parents and 7.5% in siblings.

    • Conclusions:

    • Cleft uvula exhibits a polygenic mode of inheritance.
    • The prevalence of other oral clefts and dental anomalies in affected families did not deviate from general population expectations.