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Dual-Energy Perfusion-CT in Recurrent Pancreatic Cancer - Preliminary Results
F Fritz1, S Skornitzke1, T Hackert2
1Clinic of Diagnostic and Interventional Radiology, University of Heidelberg, Germany.
Rofo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin
|May 26, 2016
Summary
Dual-energy (DE) perfusion-CT is a feasible functional imaging technique for patients after pancreatic cancer resection. While current perfusion differences are insufficient to reliably distinguish tumor recurrence from postoperative tissue, DE perfusion-CT shows promise for future diagnostic improvements.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Pancreatic cancer resection requires accurate follow-up to differentiate tumor recurrence from postoperative changes.
- Conventional CT lacks functional information, limiting diagnostic accuracy in distinguishing between recurrent malignancy and benign postoperative tissue.
- Functional imaging techniques are being explored to enhance diagnostic performance in the post-surgical setting.
Purpose of the Study:
- To evaluate the diagnostic performance of dual-energy (DE) perfusion-CT for differentiating between postoperative soft-tissue formation and tumor recurrence in patients following pancreatic cancer resection.
- To assess the feasibility of DE perfusion-CT in the clinical management of pancreatic cancer survivors.
Main Methods:
- A prospective study involving 24 patients who underwent pancreatic cancer resection with curative intent.
- Dynamic dual-source CT with 34 DE acquisitions was performed using iodinated contrast material.
- Image data were analyzed using a body-perfusion CT tool to estimate blood flow, permeability, and blood volume.
Main Results:
- Local recurrence was diagnosed in 15 patients, and unspecific postoperative tissue formation in 9 patients.
- Blood flow values in recurrence tissue trended lower than in postoperative tissue (16.6 vs. 24.7 ml/100ml/min, p=0.06), but this was not statistically significant.
- Permeability and blood volume values showed only slight, non-significant differences between recurrence and postoperative tissue.
Conclusions:
- DE perfusion-CT is a feasible functional imaging technique in patients after pancreatic cancer resection.
- Current perfusion differences are insufficient for reliable differentiation between malignancy and postoperative alterations, but the technique shows potential.
- Further studies and technical advancements are necessary to improve the diagnostic accuracy of DE perfusion-CT for recurrent pancreatic cancer.
