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Intestinal-type sinonasal adenocarcinomas: The road to molecular diagnosis and personalized treatment
Ann Hoeben1, Linda van de Winkel2, Frank Hoebers3
1Division of Medical Oncology, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands. ann.hoeben@mumc.nl.
Background:
Sinonasal intestinal-type adenocarcinomas (ITACs) are epithelial tumors of the nasal cavity and the paranasal sinuses, often related to professional exposure to organic dust, mainly wood or leather. It is a rare cancer. If resectable, surgery is the treatment of choice. Postoperative radiotherapy is often indicated to increase local control. Systemic treatment (chemotherapy, targeted agents, or immunotherapy) of irresectable ITACs and/or metastasized disease is less standardized.
Methods:
Articles on ITAC histopathology, molecular profile, and current treatment options of this specific tumor were identified and reviewed, using the electronic databases Pubmed, Medline, Cochrane, and Web of Science.
Results:
This article reviews what is currently known on the histopathology, tumorigenesis, molecular characteristics, and standardized treatment options of ITAC.
Conclusion:
More translational research is needed to identify druggable targets that may lead to a personalized treatment plan in order to improve long-term outcome in patients with locally advanced and/or metastasized ITAC. © 2016 Wiley Periodicals, Inc. Head Neck 38: First-1570, 2016.
Insights
Sinonasal intestinal-type adenocarcinomas (ITACs) are rare nasal cancers linked to occupational dust exposure. Current treatments include surgery and radiotherapy, but systemic options for advanced ITAC require further research.
Area of Science:
- Oncology
- Head and Neck Cancer Research
Background:
- Sinonasal intestinal-type adenocarcinomas (ITACs) are rare epithelial tumors.
- Often associated with occupational exposure to organic dust (wood, leather).
Purpose of the Study:
- To review current knowledge on ITAC.
- To summarize histopathology, tumorigenesis, molecular characteristics, and treatment options.
Main Methods:
- Literature review of scientific articles.
- Databases searched include Pubmed, Medline, Cochrane, and Web of Science.
Main Results:
- ITACs are rare cancers of the nasal cavity and sinuses.
- Surgery is the primary treatment for resectable ITACs.
- Postoperative radiotherapy improves local control; systemic treatments for advanced disease are less standardized.
Conclusions:
- Further translational research is essential.
- Identification of druggable targets is needed for personalized treatment.
- Improved outcomes for advanced/metastatic ITAC patients require novel therapeutic strategies.
