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Updated: Mar 20, 2026

Isolation of Adipose Tissue Immune Cells
Published on: May 22, 2013
Modulation of T Cell Activation in Obesity
Stéphanie O Morin1,2,3,4, Marjorie Poggi5,6,7, Marie-Christine Alessi5,6,7
11 Inserm, U1068, Centre de Recherche en Cancérologie de Marseille , Marseille, France .
Significance:
Immune T cells are present in adipose tissues (AT), and the stoichiometry of the different T cell subsets is altered during diet-induced obesity (DIO). T cells contribute to the early steps of AT inflammation during DIO. Recent Advances: Many factors could potentially be responsible for this altered pro-inflammatory versus anti-inflammatory T cell balance.
Critical Issues:
T cells are potentially activated in AT, which vitamin D might contribute to, as will be discussed in this article. In addition, we will review the different possible contributors to T cell activation in AT, such as the CD28 and CD154 T cell costimulatory molecules in AT.
Future Directions:
The potential antigen presentation capacities of adipocytes should be further investigated. Moreover, the properties of these AT resident (or migrating to AT) T cells must be further assessed. Antioxid. Redox Signal. 26, 489-500.
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