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A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
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Interventions for female pattern hair loss.

Esther J van Zuuren1, Zbys Fedorowicz, Jan Schoones

  • 1Department of Dermatology, Leiden University Medical Center, PO Box 9600, B1-Q, Leiden, Netherlands, 2300 RC.

The Cochrane Database of Systematic Reviews
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Topical minoxidil is effective for treating female pattern hair loss (FPHL), showing improved hair regrowth and count compared to placebo. Other treatments like finasteride showed no significant benefit, and laser therapy yielded inconsistent results.

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Area of Science:

  • Dermatology
  • Trichology
  • Pharmacology

Background:

  • Female pattern hair loss (FPHL), also known as androgenic alopecia, is the most prevalent form of hair loss in women.
  • FPHL is characterized by a shortened hair growth cycle and progressive miniaturization of hair follicles.
  • Hair loss can significantly impact a woman's psychological well-being.

Purpose of the Study:

  • To evaluate the efficacy and safety of current treatment options for female pattern hair loss (FPHL).
  • To synthesize evidence from randomized controlled trials on FPHL interventions.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) updated to July 2015.
  • Searched multiple databases including Cochrane, MEDLINE, EMBASE, and Web of Science.
  • Included 47 trials with 5290 participants; assessed risk of bias for each study.

Main Results:

  • Topical minoxidil (2% and 1%) demonstrated efficacy in promoting hair regrowth and increasing hair count compared to placebo (moderate quality evidence).
  • No significant difference in efficacy or adverse events was found between minoxidil 2% and 5% concentrations.
  • Finasteride 1 mg showed no greater efficacy than placebo, and low-level laser comb therapy produced inconsistent results for hair regrowth but increased hair count.

Conclusions:

  • Topical minoxidil is an effective and safe treatment for FPHL, supported by moderate to low quality evidence.
  • Evidence suggests no significant difference between minoxidil 2% and 5%.
  • Further RCTs are needed for other treatments like spironolactone, dutasteride, and laser therapy.