Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aldehydes and Ketones to Alkenes: Wittig Reaction Mechanism01:14

Aldehydes and Ketones to Alkenes: Wittig Reaction Mechanism

5.7K
The Wittig reaction, which converts aldehydes or ketones to alkenes using phosphorus ylides, proceeds through a nucleophilic addition‒elimination process.
The reaction begins with the nucleophilic addition between a phosphorus ylide and the carbonyl compound. Due to its carbanionic character,  phosphorus ylide acts as a strong nucleophile and attacks the electrophilic carbonyl group. This generates a charge-separated dipolar intermediate called betaine. The negatively charged oxygen atom and...
5.7K
Aldehydes and Ketones to Alkenes: Wittig Reaction Overview01:19

Aldehydes and Ketones to Alkenes: Wittig Reaction Overview

10.4K
The Wittig reaction is the conversion of carbonyl compounds-aldehydes and ketones-to alkenes using phosphorus ylides, or the Wittig reagent. The reaction was pioneered by Prof. Georg Wittig, for which he was awarded the Nobel Prize in Chemistry.
10.4K
Aryldiazonium Salts to Azo Dyes: Diazo Coupling01:11

Aryldiazonium Salts to Azo Dyes: Diazo Coupling

3.9K
The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the para...
3.9K
Coordination Number and Geometry02:57

Coordination Number and Geometry

19.5K
For transition metal complexes, the coordination number determines the geometry around the central metal ion. Table 1 compares coordination numbers to molecular geometry. The most common structures of the complexes in coordination compounds are octahedral, tetrahedral, and square planar.
19.5K
Structural Isomerism02:34

Structural Isomerism

22.4K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
22.4K
Valence Bond Theory02:42

Valence Bond Theory

11.6K
Coordination compounds and complexes exhibit different colors, geometries, and magnetic behavior, depending on the metal atom/ion and ligands from which they are composed. In an attempt to explain the bonding and structure of coordination complexes, Linus Pauling proposed the valence bond theory, or VBT, using the concepts of hybridization and the overlapping of the atomic orbitals. According to VBT, the central metal atom or ion (Lewis acid) hybridizes to provide empty orbitals of suitable...
11.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ligand-Controlled Redox and Photophysical Properties in Photoluminescent Tris-Heteroleptic Ru(II) Pyridyl-Phosphonium Ylide Complexes.

Inorganic chemistry·2026
Same author

A full-active phosphorus dendron-based nanomedicine alleviates ischemic stroke through multi-target immunomodulation and neuroprotection.

Bioactive materials·2026
Same author

A phosphorous-based dendrimer targets mitochondria and normalizes the keratinocyte proliferation/differentiation balance to improve psoriasis.

PloS one·2026
Same author

Bioactive hydroxyl-terminated phosphorus dendrimers mediate protein/drug co-delivery for enhanced multi-target ischemic stroke therapy.

Biomaterials·2026
Same author

Crystallographic Analysis under Pressure Can Resolve Ambiguity Regarding Chirality: The Case of an Imidazolium-Based Coordination Network.

Inorganic chemistry·2026
Same author

Bipyridyl Ruthenium Complexes Featuring P-Ylide Ligands: A Comparative Study of Their Redox and Photophysical Properties.

Inorganic chemistry·2025

Related Experiment Video

Updated: Mar 20, 2026

Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of PhosphorusI
08:46

Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of PhosphorusI

Published on: November 22, 2016

8.3K

Thiazoyl phosphines. Design, reactivity, and complexation.

Maria Zablocka1, Gennady Oshovsky, Carine Duhayon

  • 1Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland. zabloc@cbmm.lodz.pl.

Dalton Transactions (Cambridge, England : 2003)
|May 27, 2016
PubMed
Summary

This study details versatile modifications of thiazole derivatives, specifically thiazoyl phosphines, enabling tailored structures and properties for catalysis and medicinal chemistry applications. New ruthenium and gold complexes were synthesized and characterized.

More Related Videos

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
10:51

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes

Published on: April 10, 2015

12.8K
Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
11:44

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

Published on: March 20, 2014

26.0K

Related Experiment Videos

Last Updated: Mar 20, 2026

Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of PhosphorusI
08:46

Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of PhosphorusI

Published on: November 22, 2016

8.3K
The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
10:51

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes

Published on: April 10, 2015

12.8K
Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
11:44

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

Published on: March 20, 2014

26.0K

Area of Science:

  • Organometallic Chemistry
  • Medicinal Chemistry
  • Catalysis

Background:

  • Thiazole derivatives possess diverse applications in catalysis and medicinal chemistry.
  • Limited research exists on the versatile chemistry and structural modification of thiazoles.
  • Thiazoyl phosphines represent a key class of thiazole derivatives with significant potential.

Purpose of the Study:

  • To explore and detail selective modifications of thiazole derivatives, focusing on thiazoyl phosphines.
  • To demonstrate the ability to tailor the structure and properties of these compounds.
  • To report the synthesis and characterization of novel ruthenium and gold complexes.

Main Methods:

  • Selective chemical modifications of thiazole structures.
  • Synthesis of novel thiazoyl phosphine ligands.
  • Formation and characterization of ruthenium (Ru) and gold (Au) complexes.
  • X-ray crystallography for structural elucidation.

Main Results:

  • Several selective modifications of thiazoyl phosphines were successfully achieved.
  • New thiazoyl phosphines were synthesized, allowing for tailored structural and property tuning.
  • Ruthenium and gold complexes incorporating these ligands were formed.
  • Six novel thiazoyl phosphines and two gold complexes were structurally characterized by X-ray crystallography.

Conclusions:

  • Thiazoyl phosphines offer versatile platforms for developing new ligands and potentially active pharmaceutical ingredients.
  • The reported synthetic strategies allow for precise control over molecular structure and properties.
  • The characterized complexes provide a foundation for further investigations in catalysis and medicinal chemistry.