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The chicken erythrocyte epigenome.

Sanzida Jahan1, Wayne Xu1, Shihua He1

  • 1Children's Hospital Research Institute of Manitoba, University of Manitoba, 715 McDermot Avenue, Room 600A, Winnipeg, MB R3E 3P4 Canada.

Epigenetics & Chromatin
|May 27, 2016
PubMed
Summary

Researchers mapped active chromosomal domains in chicken erythrocytes, revealing distinct salt-soluble chromatin structures for highly expressed genes. This provides a genome-wide view of chromatin organization and gene expression.

Keywords:
Chicken erythrocyte transcriptomeChromatin fractionationChromosomal domainsH3K27acH3K4me3Histone acetylationHistone methylation

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Area of Science:

  • Genomics
  • Epigenetics
  • Chromatin Biology

Background:

  • Transcriptional regulation is influenced by genome organization.
  • Active chromatin is DNase I-sensitive and acetylated, but few such domains are characterized.
  • Chicken erythrocyte chromatin's active domains prevent insolubility.

Purpose of the Study:

  • To identify and map all transcriptionally active chromosomal domains in chicken polychromatic erythrocytes.
  • To characterize the chromatin organization of these active domains.
  • To correlate chromatin signatures with gene expression levels.

Main Methods:

  • Chromatin fractionation
  • Next-generation DNA sequencing
  • Next-generation RNA sequencing

Main Results:

  • Two classes of transcribed chromatin organizations were identified based on solubility.
  • Highly transcribed genes reside in multigenic, salt-soluble domains (30-150 kb).
  • Over 100 highly expressed genes showed dynamic acetylation, H3K4me3, H3K27ac, and antisense transcripts in soluble domains.

Conclusions:

  • A genome-wide profile of chromatin signatures linked to expression levels in chicken polychromatic erythrocytes was generated.
  • This study elucidates the relationship between chromatin structure and gene activity in a specific cellular context.