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Links between thermoregulation and aging in endotherms and ectotherms
Andreas D Flouris1, Carla Piantoni2
1FAME Laboratory; Department of Exercise Science; University of Thessaly ; Trikala, Greece.
Temperature (Austin, Tex.)
|May 27, 2016
Summary
Lowering body temperature may extend lifespan in both endotherms and ectotherms. Understanding the precise thermoregulatory mechanisms is key to unlocking longevity benefits and compressing morbidity.
Area of Science:
- Gerontology
- Physiology
- Thermoregulation
Background:
- Thermoregulation is linked to aging, but underlying pathways require elucidation.
- Optimal body temperature zones are defended physiologically and behaviorally, impacting senescence.
- Low body temperature is counterintuitive to medical theory but studied for longevity.
Purpose of the Study:
- To review and scrutinize thermoregulatory mechanisms in aging endotherms and ectotherms.
- To analyze the impact of body temperature on lifespan across different organisms.
- To discuss the potential of temperature regulation in compressing morbidity and reducing mortality risk.
Main Methods:
- Literature review and critical analysis of existing research on thermoregulation and aging.
- Comparative analysis of findings in endothermic and ectothermic organisms.
- Discussion of physiological and molecular mechanisms linking body temperature and longevity.
Main Results:
- Low body temperature appears to benefit lifespan in both endotherms and ectotherms.
- Endotherm research offers deeper insights into molecular mechanisms of temperature-longevity links.
- Ectotherm research is growing, but requires further mechanistic exploration.
Conclusions:
- Thermoregulatory mechanisms play a significant role in organismal aging.
- Lowering body temperature shows potential for lifespan extension and healthspan improvement.
- Further research is needed to fully understand and harness temperature regulation for longevity.
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