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The importance of systematic approaches in the study of emesis

Bart C De Jonghe1, Charles C Horn2

  • 1University of Pennsylvania; School of Nursing; Department of Biobehavioral Health Sciences ; Philadelphia, PA USA.

Temperature (Austin, Tex.)
|May 27, 2016
PubMed

Insights

Nausea and vomiting (emesis) are common side effects of clinical treatments. Research suggests the TRPV1 receptor may be a potential target for anti-emetic drugs, offering new hope for managing these symptoms.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Gastroenterology

Background:

  • Nausea and vomiting (emesis) are common and distressing human experiences.
  • These symptoms frequently occur as side effects of various medical treatments.
  • The precise neural mechanisms underlying emesis are not fully understood despite extensive research.

Purpose of the Study:

  • To explore the potential of Transient Receptor Potential Vanilloid 1 (TRPV1) as a pharmacological target for anti-emetic therapies.
  • To investigate the understudied role of TRPV1 in the neural pathways of nausea and vomiting.

Main Methods:

  • This study reviews existing research on the neural pathways of emesis.
  • It specifically examines the expression and function of TRPV1 in relevant neuronal circuits.
  • Pharmacological data regarding TRPV1 modulation and its effects on emesis are analyzed.

Main Results:

  • TRPV1 channels are expressed in key areas of the brainstem involved in emesis.
  • Modulation of TRPV1 activity has shown promise in preclinical models for reducing nausea and vomiting.
  • TRPV1 represents a potentially novel target for anti-emetic drug development.

Conclusions:

  • The TRPV1 receptor is a promising, yet understudied, target for developing new anti-emetic treatments.
  • Further research into TRPV1's role in emesis could lead to improved management of treatment-induced nausea and vomiting.
Keywords:
RTXSuncus murinusanti-emeticcapsaicinferretnauseatranslational drug developmentvanilloidvomiting

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