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Updated: Mar 20, 2026
Thermal Ablation for the Treatment of Abdominal Tumors
Published on: March 7, 2011
Is alcohol required for effective pancreatic cyst ablation? The prospective randomized CHARM trial pilot study
Matthew T Moyer1, Charles E Dye1, Setareh Sharzehi1
1Penn State Hershey Medical Center - Gastroenterology and Hepatology, Hershey, Pennsylvania, United States.
Background And Study Aims:
In this study, we aim to determine the safety and feasibility of an alcohol-free approach to pancreatic cyst ablation using a chemotherapeutic ablation cocktail.
Patients And Methods:
In this prospective, randomized, double-blinded pilot study, 10 patients with known mucinous type pancreatic cysts underwent endoscopic ultrasound (EUS)-guided fine needle aspiration and then lavage with either 80 % ethanol or normal saline. Both groups were then treated with a cocktail of paclitaxel and gemcitabine. Primary outcomes were reduction in cyst volume and rates of complications.
Results:
At 6 months, patients randomized to the alcohol arm had an 89 % average volume reduction, with a 91 % reduction noted in the alcohol-free arm. Complete ablation was achieved in 67 % of patients in the alcohol-free arm at both 6 and 12 months, whereas the alcohol group recorded complete ablation rates of 50 % and 75 % at 6 and 12 months, respectively. One patient in the alcohol arm developed acute pancreatitis (20 %) with no adverse events in the alcohol-free arm.
Conclusions:
This study revealed similar ablation rates between the alcohol ablation group and the alcohol-free arm and demonstrates the safety and feasibility of an alcohol-free ablation protocol. This pilot study suggests that alcohol may not be required for effective cyst ablation.
