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Updated: Mar 20, 2026

A Human Fallopian Tube Model for Investigation of C. trachomatis Infections
Published on: August 11, 2012
Lack of Significant Effects of Chlamydia trachomatis Infection on Cervical Adenocarcinoma Risk: Nested Case-Control
Vitaly Smelov1,2,3, Tarik Gheit1, Karin Sundström3
1Infections and Cancer Biology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France.
Background:
A role of Chlamydia trachomatis in HPV-induced cervical carcinogenesis has been reported for cervical cancer but studies on cervical adenocarcinoma are limited.
Methods:
A total of 1,553 cervical smears taken up to 26 years before diagnosis in a large population-based nested case-control study of cervical adenocarcinoma (AC, 132 cases with matched controls), and adenocarcinoma in situ (AIS, 159 cases with matched controls) were tested for C. trachomatis and HPV DNA by a type-specific PCR bead-based multiplex genotyping (TS-MPG) assay.
Results:
Only 1.7% of samples were positive for C. trachomatis, with no significant differences between AC/AIS cases and controls. HPV-positivity was detected in 49.3% of C. trachomatis-negative and 65.4% C. trachomatis-positive samples, respectively.
Conclusions:
A large prospective study did not find any risk for cervical adenocarcinoma and/or AIS conferred by C. trachomatis infection.
Impact:
C. trachomatis appears not to be involved in cervical adenocarcinomas.
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