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Plasma Soluble (Pro)renin Receptor Reflects Renal Damage
Naro Ohashi1, Shinsuke Isobe1, Sayaka Ishigaki1
1Internal Medicine 1, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, Japan.
Plos One
|May 27, 2016
Summary
Plasma soluble (Pro)renin receptor [s(P)RR] levels correlate with kidney damage markers. This suggests s(P)RR in blood may indicate tubulointerstitial fibrosis and serve as a renal damage surrogate.
Area of Science:
- Nephrology
- Renal Physiology
- Biomarker Discovery
Background:
- The (Pro)renin receptor [(P)RR] is part of the renin-angiotensin system.
- Soluble (P)RR [s(P)RR] is released into circulation.
- Previous studies linked s(P)RR to urinary protein, a marker of kidney damage.
Purpose of the Study:
- To investigate if plasma s(P)RR levels reflect actual renal damage.
- To determine the relationship between s(P)RR and tubulointerstitial fibrosis.
Main Methods:
- Studied 25 patients undergoing heminephrectomy.
- Measured pre-operative plasma s(P)RR levels.
- Assessed renal damage via tubulointerstitial fibrosis and immunohistochemistry for (P)RR and immune cell markers (CD3, CD19, CD68).
Main Results:
- Plasma s(P)RR showed a significant positive correlation with tubulointerstitial fibrosis.
- (P)RR expression was elevated in infiltrated mononuclear cells (CD3+, CD68+), not renal tubules or vessels.
- These correlations held after adjusting for clinical factors and RAS blocker use.
Conclusions:
- Plasma s(P)RR levels may serve as a surrogate marker for renal damage.
- Elevated s(P)RR reflects (P)RR expression in infiltrating immune cells within the kidney.
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