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Updated: Mar 20, 2026

Integrative Toolkit to Analyze Cellular Signals: Forces, Motion, Morphology, and Fluorescence

Integrative Toolkit to Analyze Cellular Signals: Forces, Motion, Morphology, and Fluorescence

Published on: March 5, 2022

TissueMiner: A multiscale analysis toolkit to quantify how cellular processes create tissue dynamics.

Raphaël Etournay^1,2, Matthias Merkel^3,4, Marko Popović³

¹Division of Cell Polarity, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.

|May 27, 2016

Summary

This summary is machine-generated.

We developed TissueMiner, a computational framework to analyze cell and tissue dynamics in developing organisms. This tool reveals how cell behaviors, like convergent extension, shape tissues, uncovering new insights into morphogenesis.

Keywords:

D. melanogaster cell biology computational biology epithelial cells epithelial dynamics systems biology

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Last Updated: Mar 20, 2026

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A High-throughput Cell Microarray Platform for Correlative Analysis of Cell Differentiation and Traction Forces

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Published on: March 1, 2017

Area of Science:

Developmental biology
Computational biology
Cell biology

Background:

Cellular choreography drives tissue shape changes in developing organisms.
Analyzing large datasets from time-lapse experiments is challenging.
Complex computational methods limit the application of advanced analyses in biology.

Purpose of the Study:

To create a database format and computational tools for analyzing cell and tissue dynamics.
To enable multi-scale analysis of morphogenesis in deforming epithelial tissues.
To make advanced computational methods for developmental biology more accessible to researchers.

Main Methods:

Developed a database format for cellular connectivity and geometry.
Created computational tools for interrogating deforming tissue data.
Applied the framework to analyze cell and tissue dynamics in Drosophila pupal wings.

Main Results:

Successfully stored and interrogated large datasets of cellular dynamics.
Enabled multi-scale analysis of tissue morphogenesis.
Identified an unexpected role for convergent extension in shaping wing veins in Drosophila.

Conclusions:

TissueMiner provides a powerful, accessible framework for analyzing complex biological datasets.
The developed tools facilitate the study of morphogenesis at multiple scales.
Convergent extension is a key mechanism in the development of wing vein structures.