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Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
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Quantitative MRI to understand Alzheimer's disease pathophysiology
Marco Bozzali1, Laura Serra, Mara Cercignani
1aNeuroimaging Laboratory, IRCCS Santa Lucia Foundation, Via Ardeatina, Rome, Italy bBrighton and Sussex Medical School, CISC, University of Sussex, Brighton, Falmer, East Sussex, UK.
Current Opinion in Neurology
|May 27, 2016
Summary
White matter damage is an early indicator in Alzheimer's disease progression and cognitive decline. Advanced MRI techniques help identify biomarkers for diagnosis and prognosis.
Area of Science:
- Neuroimaging
- Neuropathology
- Alzheimer's Disease Research
Background:
- White matter damage plays a crucial role in Alzheimer's disease (AD) progression and cognitive impairment.
- Diffusion tensor imaging (DTI) and other quantitative MRI techniques provide in vivo insights into AD pathophysiology.
Purpose of the Study:
- To review recent imaging findings related to AD pathophysiology.
- To identify potential diagnostic and prognostic biomarkers for Alzheimer's disease.
Main Methods:
- Review of current literature integrating diffusion tensor imaging and quantitative MRI findings.
- Analysis of imaging data in relation to cognitive performance and neuropathology.
Main Results:
- White matter damage in AD is concentrated in tracts connecting the temporal lobe, including the cingulum, uncinate fasciculus, and fornix.
- These abnormalities correlate with gray matter loss and cognitive deficits, supporting a disconnection hypothesis in AD.
- White matter changes are early events in AD and may drive disease progression.
Conclusions:
- White matter abnormalities are integral to Alzheimer's disease pathogenesis and cognitive decline.
- Multiparametric biomarkers combining structural and functional imaging are likely to be most effective for AD diagnosis and prognosis.
