Related Experiment Video
Updated: Mar 20, 2026
Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
Published on: January 12, 2022
BILATERAL COATS REACTION IN BANNAYAN-ZONANA SYNDROME: A SINGLE CASE REPORT
Meredith R Klifto1, Chandrakumar Balaratnasingam, Harold H Weissman
1*Vitreous-Retina-Macula Consultants of New York, New York, New York; †The LuEsther T. Mertz Retinal Research Center, New York, New York; ‡Department of Ophthalmology, New York University School of Medicine, New York, New York; §Department of Physiology and Pharmacology, Centre for Ophthalmology and Visual Sciences, Lions Eye Institute, University of Western Australia, Perth, Australia; and ¶Department of Ophthalmology, New York-Presbyterian, New York, New York.
Purpose:
To report the clinical features of bilateral Coats reaction in a patient with Bannayan-Zonana syndrome.
Methods:
The clinical course and retinal manifestations of a 21-year-old patient with Bannayan-Zonana syndrome and bilateral Coats reaction were studied. Retinal manifestations were documented with clinical examination, ultrawide-field color imaging, and ultrawide-field fluorescein angiography.
Results:
Best-corrected visual acuities were 20/25 OD and 20/25 OS. Anterior segment examinations were normal bilaterally. The inferotemporal quadrant of the left retina demonstrated retinal telangiectasias, exudation, and a neurosensory retinal detachment extending to the mid-periphery. Fluorescein angiography demonstrated bilateral peripheral nonperfusion and vascular staining. An epiretinal membrane also involved the left macula.
Conclusion:
Bannayan-Zonana syndrome is an autosomal-dominant, hamartomatous disease characterized by a mutation spectrum that involves genes responsible for vascular development. Retinal vascular abnormalities and exudation can be a manifestation of this syndrome.
