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A male accessory gland peptide with protease inhibitory activity in Drosophila funebris
T Schmidt1, E Stumm-Zollinger, P S Chen
1Zoology Institute, University of Zurich, Switzerland.
The Journal of Biological Chemistry
|June 15, 1989
Abstract:
Male accessory glands of Drosophila funebris synthesize and secrete a peptide that shows a protease-inhibiting activity. Amino acid sequencing of the purified peptide revealed that the peptide consists of 63 amino acid residues. It is a serine protease inhibitor belonging to the pancreatic trypsin inhibitor (Kunitz) family. The inhibitory function and the kinetic characteristics of the inhibition have been examined with various substrates. The peptide possibly plays a role as an acrosin inhibitor involved in Drosophila reproduction.