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Implantation of Left Ventricular Assist Device (LVAD) in Juvenile Landrace Swine: A LVAD Implantation Model of Pediatric Heart Failure
Published on: January 16, 2026
133
Physiologic effects of continuous-flow left ventricular assist devices.
Aaron H Healy1, Stephen H McKellar1, Stavros G Drakos2
1Department of Surgery, University of Utah, Salt Lake City, Utah.
The Journal of Surgical Research
|May 28, 2016
Summary
Continuous-flow left ventricular assist devices (LVADs) are now standard care, but their unique physiology impacts organ systems. While generally well-tolerated, increased gastrointestinal bleeding is a notable concern requiring further study.
Area of Science:
- Cardiovascular Physiology
- Mechanical Circulatory Support
Background:
- Continuous-flow left ventricular assist devices (LVADs) have become the standard of care, replacing pulsatile-flow devices.
- Understanding the physiological effects of continuous-flow LVADs is still evolving.
Purpose of the Study:
- To review the physiological and clinical effects of continuous-flow physiology on various organ systems.
- To analyze the impact of continuous-flow LVADs compared to pulsatile-flow devices.
Main Methods:
- Comprehensive literature review of scientific studies on continuous-flow physiology.
- Organ system-based analysis including cardiovascular, respiratory, hematologic, gastrointestinal, renal, hepatic, neurologic, immunologic, and endocrine systems.
Main Results:
- Continuous-flow physiology is generally well-tolerated long-term.
- Organ system changes occur, with some, like increased gastrointestinal bleeding, having clinical significance.
Conclusions:
- Continuous-flow LVADs offer advantages in size and durability over pulsatile devices.
- While physiological effects are limited, challenges remain, necessitating combined clinical and engineering solutions for future advancements.
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