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Ocular morphology and visual function in relation to general growth in moderate-to-late preterm school-aged children

Lina H Raffa1,2, Jovanna Dahlgren3, Ann Hellström4

  • 1Department of Ophthalmology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden. lina_raffa@yahoo.com.

Acta Ophthalmologica
|May 28, 2016
PubMed

Insights

Moderate-to-late preterm children have reduced macular volume at age eight. General growth and insulin-like growth factor I (IGF-I) influence ocular development in these children.

Area of Science:

  • Ophthalmology
  • Pediatric Growth Studies
  • Developmental Biology

Background:

  • Preterm birth can impact long-term health and development.
  • Ocular development may be affected by growth factors and overall growth patterns.

Purpose of the Study:

  • To investigate ocular morphology and visual function in relation to general growth in moderate-to-late preterm (MLP) children.
  • To compare ocular parameters between MLP children and full-term controls.

Main Methods:

  • Evaluated visual acuity, refraction, optic disc parameters, and anthropometric measures in 50 eight-year-old MLP children and 43 full-term controls.
  • Assessed macular parameters using optical coherence tomography.
  • Analyzed serum insulin-like growth factor I (IGF-I) levels at birth and follow-up.

Main Results:

  • MLP children exhibited significantly reduced total macular volume compared to controls.
  • Macular volume correlated with head circumference and refraction in MLP children.
  • Central retinal thickness showed significant correlations with delta IGF-I and refraction; optic disc area correlated with weight and height.

Conclusions:

  • MLP children have significantly less macular volume at 8 years of age.
  • General growth and IGF-I levels appear to play a role in ocular development and morphology in children born moderate-to-late preterm.
Abstract

Keywords:
insulin-like growth factor I (IGF-I)macular thicknessmoderate-to-late pretermoptical coherence tomography

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