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Related Experiment Video

Updated: Mar 20, 2026

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care
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Endothelial and Microcirculatory Function and Dysfunction in Sepsis.

James F Colbert1, Eric P Schmidt2

  • 1Division of Infectious Diseases, Department of Medicine, University of Colorado School of Medicine, 12700 E. 19th Avenue, Aurora, CO 80045, USA.

Clinics in Chest Medicine
|May 28, 2016
PubMed
Summary
This summary is machine-generated.

The microcirculation, vital for organ health, can become harmful when overactive during infection. Personalized treatments targeting microcirculatory dysfunction are needed to improve patient outcomes in sepsis.

Keywords:
GlycocalyxGlycosaminoglycansHeparan sulfateIntravital microscopyMicrocirculationSepsis

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Area of Science:

  • Physiology
  • Pathology
  • Microcirculation Research

Background:

  • The microcirculation ensures organ-specific oxygen and nutrient delivery.
  • An overactive or dysregulated microcirculatory response to infection can be detrimental.
  • Microcirculatory dysfunction is a key factor in sepsis pathophysiology.

Purpose of the Study:

  • To highlight the dual role of microcirculation in infection.
  • To discuss methods for assessing microcirculatory dysfunction.
  • To emphasize the need for personalized sepsis therapeutics.

Main Methods:

  • Intravital microscopy for direct visualization of microcirculation.
  • Detection of circulating biomarkers for indirect measurement.
  • Review of existing sepsis therapeutics and their limitations.

Main Results:

  • Pathologic microcirculatory dysfunction can be visualized and measured.
  • Current sepsis treatments lack efficacy when applied indiscriminately.
  • Protecting microcirculation in sepsis requires tailored approaches.

Conclusions:

  • Microcirculatory dysfunction significantly impacts sepsis outcomes.
  • Indiscriminate treatment strategies for sepsis are ineffective.
  • Future research should focus on personalized therapeutics targeting microcirculatory dysfunction for improved patient outcomes.