Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Metabolomic signatures of dietary carbohydrates and differential association with type 2 diabetes.

Nature health·2026

Same author

Fasciola hepatica excretory-secretory products attenuate demyelination and reduce neuroinflammation in the Cuprizone -induced multiple sclerosis model.

PloS one·2026

Same author

Epigenetic and genetic insights for tailored therapeutic strategies in multiple sclerosis.

Personalized medicine·2026

Same author

Prevalence and Molecular Characterization of <i>Cryptosporidium</i> Species in Patients With Hematologic Malignancies in Eastern Iran.

International journal of microbiology·2026

Same author

Molecular Identification of <i>Toxoplasma gondii</i> Isolates From Spontaneous Abortion Placentas in Women in Eastern Iran.

Journal of parasitology research·2026

Same author

Hospital-Based Surveillance and Resistance Index Analysis of Antimicrobial Resistance Trends: A Three-Year Study from a Tertiary Hospital in Iran (2021-2023).

Infection and drug resistance·2026

Search research articles

Related Experiment Video

Updated: Mar 20, 2026

Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix

Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix

Published on: July 10, 2020

Rhabdomyosarcoma in a Silver Carp.

Annahita Rezaie¹, Seyed Mohammad Mousavi², Mahshid Bagherzadeh Ansari¹

¹a Department of Pathobiology, Faculty of Veterinary Medicine , Shahid Chamran University of Ahvaz, Campus Delivery, Building of Faculty of Veterinary Medicine , Golestan Boulevard , Ahvaz 61357-831351 , Iran.

Journal of Aquatic Animal Health

|May 28, 2016

Summary

This study reports the first case of rhabdomyosarcoma, a skeletal muscle tumor, found in a Silver Carp (Hypophthalmichthys molitrix). The tumor exhibited characteristic spindle cells and cross striations, confirming the diagnosis in this fish species.

More Related Videos

Screening for Melanoma Modifiers using a Zebrafish Autochthonous Tumor Model

Screening for Melanoma Modifiers using a Zebrafish Autochthonous Tumor Model

Published on: November 13, 2012

Normal and Malignant Muscle Cell Transplantation into Immune Compromised Adult Zebrafish

Normal and Malignant Muscle Cell Transplantation into Immune Compromised Adult Zebrafish

Published on: December 26, 2014

Related Experiment Videos

Last Updated: Mar 20, 2026

Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix

Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix

Published on: July 10, 2020

Screening for Melanoma Modifiers using a Zebrafish Autochthonous Tumor Model

Screening for Melanoma Modifiers using a Zebrafish Autochthonous Tumor Model

Published on: November 13, 2012

Normal and Malignant Muscle Cell Transplantation into Immune Compromised Adult Zebrafish

Normal and Malignant Muscle Cell Transplantation into Immune Compromised Adult Zebrafish

Published on: December 26, 2014

Area of Science:

Ichthyopathology
Comparative Oncology
Aquatic Animal Health

Background:

Rhabdomyosarcoma is a malignant neoplasm originating from skeletal muscle progenitor cells.
Understanding tumor development in fish is crucial for aquaculture health and conservation efforts.

Observation:

A raised, firm, pink mass (5 × 4 × 3 cm) was identified on the dorsolateral surface of a 2-year-old female Silver Carp.
The mass appeared to originate from the subcutaneous musculature of the fish.

Findings:

Histological examination revealed a tumor composed of densely packed spindle cells arranged in interwoven bundles.
Microscopic features included vesicular nuclei, nuclear pleomorphism, multinucleate giant cells, and eosinophilic cytoplasm with visible cross striations.
Masson's trichrome staining confirmed the presence of striated fibrils, consistent with rhabdomyosarcoma.

Implications:

This is the first documented instance of rhabdomyosarcoma in Silver Carp (Hypophthalmichthys molitrix).
The findings contribute to the knowledge of neoplasia in cyprinid fish.
This case highlights the importance of monitoring fish populations for neoplastic diseases.