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Updated: Mar 20, 2026

One-step Metabolomics: Carbohydrates, Organic and Amino Acids Quantified in a Single Procedure
Published on: June 25, 2010
How to Choose the Best Metabolic Procedure?
Lidia Castagneto Gissey1,2, James Rossario Casella Mariolo3,4, Geltrude Mingrone5,6
1Department of General Surgery, University of Rome "La Sapienza", Rome, Italy. lidia.castagnetogissey@nhs.net.
Bariatric surgery aids diabetes remission and weight loss but carries risks like vitamin deficiencies and complications. Careful patient selection and monitoring are crucial for balancing benefits and risks.
Area of Science:
- Metabolic Surgery
- Endocrinology
- Gastroenterology
Background:
- Bariatric/metabolic surgery effectively treats type 2 diabetes, obesity, and cardiovascular risk factors.
- Despite benefits, patients may experience hyperglycemia relapse, mortality, and complications.
- Metabolic complications, including vitamin deficiencies, arise from malabsorption and poor patient compliance.
Purpose of the Study:
- To review the benefits and risks of bariatric/metabolic surgery.
- To highlight the challenges in vitamin and trace element supplementation post-surgery.
- To inform practitioners about clinical effects of metabolic dysfunction and guide surgical procedure selection.
Main Methods:
- Literature review of bariatric/metabolic surgery outcomes.
- Analysis of metabolic complications and patient compliance.
- Discussion of clinical effects and management strategies.
Main Results:
- Surgery induces diabetes remission, weight loss, and improves cardiovascular risk.
- Low mortality but significant early and late complications, notably vitamin deficiencies.
- Lack of awareness among healthcare providers regarding post-surgical metabolic dysfunction.
Conclusions:
- The choice of bariatric/metabolic surgery requires balancing significant benefits against potential risks.
- Addressing vitamin deficiencies and improving patient compliance are critical for long-term success.
- Enhanced practitioner education is needed to manage post-surgical metabolic complications effectively.
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