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In Vivo Vascular Injury Readouts in Mouse Retina to Promote Reproducibility
Published on: April 21, 2022
Inter-observer Variability in Scoring Ultra-wide-field Fluorescein Angiography in Patients with Behçet Retinal
Sang Woong Moon1, Bo Hyuck Kim2, Un Chul Park2
1a Department of Ophthalmology , Kyung Hee University College of Medicine , Seoul , Korea.
Purpose:
To test inter-observer agreement in applying the scoring system of the Angiography Scoring of Uveitis Working Group (ASUWG) to ultra-wide-field fluorescein angiograms (UWFA) obtained from patients with Behçet retinal vasculitis.
Methods:
Both standard FA and UWFA images were obtained from 21 patients with retinal vasculitis associated with Behçet disease. Three graders independently graded 21 series of standard FA and 21 series of UWFA images. Spearman rank correlation and the intra-class correlation coefficient (ICC) were used to analyze the correlations.
Results:
Total scores of all angiographic signs observed in both UWFA and standard FA images were significantly correlated between each pair of graders and among the three graders (ICC of standard FA = 0.874, p<0.001; ICC of UWFA = 0.928, p<0.001).
Conclusions:
The ASUWG scoring system is a reliable method of scoring UWFA images with regard to judging the activity of retinal vasculitis in ocular Behçet disease.
