Related Experiment Video

Updated: Mar 20, 2026

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model
05:58

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

719

Cooling down inflammation in type 2 diabetes: how strong is the evidence for cardiometabolic benefit?

Maria Ida Maiorino1, Giuseppe Bellastella2, Dario Giugliano2

  • 1Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Endocrinology and Metabolic Diseases Unit, Second University of Naples, Piazza L. Miraglia n° 2, 80138, Naples, Italy. mariaida.maiorino@unina2.it.

Endocrine
|May 28, 2016
PubMed

Insights

Anti-inflammatory drugs show modest effects on glycemic control in type 2 diabetes patients. While promising, further research is needed to confirm benefits for cardiovascular complications and blood sugar management.

Area of Science:

  • Endocrinology
  • Cardiology
  • Immunology

Background:

  • Chronic inflammation is a key factor in cardiometabolic dysfunction associated with type 2 diabetes.
  • Numerous anti-inflammatory drugs have been investigated for their potential to manage type 2 diabetes complications.

Purpose of the Study:

  • To review evidence from randomized controlled trials on the efficacy of anti-inflammatory drugs in improving glycemic control and reducing cardiovascular events in type 2 diabetes patients.
  • To assess the current status and future directions of targeting inflammation for managing type 2 diabetes.

Main Methods:

  • Systematic review of randomized controlled trials published up to March 2016, sourced from PubMed.
  • Evaluation of drugs including hydroxychloroquine, anti-tumor necrosis factor therapies, salsalate, interleukin-1 antagonists, and CC-R2 antagonists.

Main Results:

  • Most clinical trials demonstrated only modest improvements in HbA1c or glucose control with anti-inflammatory agents.
  • A trial of losmapimod (p38 inhibitor) in acute myocardial infarction patients, including those with diabetes, did not reduce major ischemic cardiovascular events.

Conclusions:

  • Current evidence suggests limited clinical benefit of anti-inflammatory drugs on glycemic control in type 2 diabetes.
  • Further research is required to determine if targeting inflammation pathways can effectively reduce cardiovascular complications and improve glycemic control in type 2 diabetes.
Keywords:
Anti-inflammatory drugsCardiovascular complicationsGlycemic controlInflammationType 2 diabetes

More Related Videos

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

1.7K
Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

1.1K

Related Concept Videos

Carbohydrate Metabolism01:36

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
14.9K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.4K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
604
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.9K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
1.4K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.7K